Immune responses in serum and respiratory secretions following vaccination with a live cold‐recombinant (cr35) and inactivated a/ussr/77 (h1n1) influenza virus vaccine
Identifieur interne : 002616 ( Main/Exploration ); précédent : 002615; suivant : 002617Immune responses in serum and respiratory secretions following vaccination with a live cold‐recombinant (cr35) and inactivated a/ussr/77 (h1n1) influenza virus vaccine
Auteurs : John M. Zahradnik [États-Unis] ; Julius A. Kasel [États-Unis] ; R. Russell Martin [États-Unis] ; Howard R. Six [États-Unis] ; Thomas R. Cate [États-Unis]Source :
- Journal of Medical Virology [ 0146-6615 ] ; 1983.
English descriptors
- Teeft :
- Adult volunteers, Antibody, Antibody response, Antibody responses, Antibody titer, Apparent tendency, Assay, Attenuated, Baylor college, Booster dose, Bronchopulmonary lavage specimens, Clinical evaluation, Compartmental distribution, Elderly persons, Fulk, Hemagglutinin, Hemagglutinin antibody, Hemagglutinin antibody responses, Hemagglutinin responses, Hln1, Iminactivated groups, Immune response, Immunization, Immunoglobulin class, Immunology, Infectious disease, Influenza, Influenza research center, Influenza vaccine, Influenza virus, Influenza virus vaccine, Influenza virus vaccines, Intranasal administration, Kasel, Lavage, Local antibody production, Lung lavage fluids, Lung lavage specimens, Nasal, Nasal secretions, Nasal wash, Nasal wash specimens, Nasal washes, Nasal washings, Neutralizing, Neutralizing antibody responses, Prevaccine antibody, Secretory, Serum antibody response, Serum antibody responses, Serum neutralizing antibody titers, Significant differences, Vaccination, Vaccine, Vaccine administration, Vaccine group, Vaccine subgroups, Vaccine type, Virus vaccine, Waldman, World health organization.
Abstract
One hundred adult volunteers were administered inactivated vaccine (20 m̈g/0.5 cc) intramuscularly (IM) or intranasally (IN), or 104.7 TCID50 of a live coldadapted vaccine (CR35) IN. Microneutralization (Nt) and radioimmunoprecipitation methods were employed to measure hemagglutinin antibody responses in sera, nasal washes, and in bronchopulmonary lavage fluids. In unprimed recipients, the relative frequency of serum antibody response and magnitude of rise was highest following the IM‐inactivated vaccine (100%) and lowest after IN‐live vaccine (29%). However, in individuals with pre‐existing antibody, the three vaccines given were comparably immunogenic. Occurrences of secretory IgA hemagglutinin antibody in nasal washings were more frequently associated with topical administration of live or inactivated vaccine, whereas, IgG hemagglutinin antibody responses occurred with equal frequency in nasal washings in all three vaccine groups. Analysis of the hemagglutinin antibody responses in the lower respiratory tract showed that the IN‐live vaccine favored the induction of secretory IgA hemagglutinin antibody and the IM‐inactivated vaccine stimulated a more frequent IgG hemagglutinin antibody response.
Url:
DOI: 10.1002/jmv.1890110403
Affiliations:
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Zahradnik</name><affiliation wicri:level="3"><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><wicri:orgArea>The Influenza Research Center, the Department of Microbiology and Immunology, Baylor College of Medicine</wicri:orgArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Correspondence address: The Influenza Research Center, Baylor College of Medicine, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Kasel, Julius A" sort="Kasel, Julius A" uniqKey="Kasel J" first="Julius A." last="Kasel">Julius A. Kasel</name><affiliation wicri:level="3"><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><wicri:orgArea>The Influenza Research Center, the Department of Microbiology and Immunology, Baylor College of Medicine</wicri:orgArea></affiliation></author><author><name sortKey="Martin, R Russell" sort="Martin, R Russell" uniqKey="Martin R" first="R. Russell" last="Martin">R. Russell Martin</name><affiliation wicri:level="3"><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><wicri:orgArea>Department of Medicine, Baylor College of Medicine</wicri:orgArea></affiliation></author><author><name sortKey="Six, Howard R" sort="Six, Howard R" uniqKey="Six H" first="Howard R." last="Six">Howard R. Six</name><affiliation wicri:level="3"><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><wicri:orgArea>The Influenza Research Center, the Department of Microbiology and Immunology, Baylor College of Medicine</wicri:orgArea></affiliation></author><author><name sortKey="Cate, Thomas R" sort="Cate, Thomas R" uniqKey="Cate T" first="Thomas R." last="Cate">Thomas R. Cate</name><affiliation wicri:level="3"><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><wicri:orgArea>Department of Medicine, Baylor College of Medicine</wicri:orgArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Medical Virology</title><title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno type="ISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><imprint><biblScope unit="vol">11</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="277">277</biblScope><biblScope unit="page" to="285">285</biblScope><biblScope unit="page-count">9</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="1983">1983</date></imprint><idno type="ISSN">0146-6615</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0146-6615</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Adult volunteers</term><term>Antibody</term><term>Antibody response</term><term>Antibody responses</term><term>Antibody titer</term><term>Apparent tendency</term><term>Assay</term><term>Attenuated</term><term>Baylor college</term><term>Booster dose</term><term>Bronchopulmonary lavage specimens</term><term>Clinical evaluation</term><term>Compartmental distribution</term><term>Elderly persons</term><term>Fulk</term><term>Hemagglutinin</term><term>Hemagglutinin antibody</term><term>Hemagglutinin antibody responses</term><term>Hemagglutinin responses</term><term>Hln1</term><term>Iminactivated groups</term><term>Immune response</term><term>Immunization</term><term>Immunoglobulin class</term><term>Immunology</term><term>Infectious disease</term><term>Influenza</term><term>Influenza research center</term><term>Influenza vaccine</term><term>Influenza virus</term><term>Influenza virus vaccine</term><term>Influenza virus vaccines</term><term>Intranasal administration</term><term>Kasel</term><term>Lavage</term><term>Local antibody production</term><term>Lung lavage fluids</term><term>Lung lavage specimens</term><term>Nasal</term><term>Nasal secretions</term><term>Nasal wash</term><term>Nasal wash specimens</term><term>Nasal washes</term><term>Nasal washings</term><term>Neutralizing</term><term>Neutralizing antibody responses</term><term>Prevaccine antibody</term><term>Secretory</term><term>Serum antibody response</term><term>Serum antibody responses</term><term>Serum neutralizing antibody titers</term><term>Significant differences</term><term>Vaccination</term><term>Vaccine</term><term>Vaccine administration</term><term>Vaccine group</term><term>Vaccine subgroups</term><term>Vaccine type</term><term>Virus vaccine</term><term>Waldman</term><term>World health organization</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">One hundred adult volunteers were administered inactivated vaccine (20 m̈g/0.5 cc) intramuscularly (IM) or intranasally (IN), or 104.7 TCID50 of a live coldadapted vaccine (CR35) IN. Microneutralization (Nt) and radioimmunoprecipitation methods were employed to measure hemagglutinin antibody responses in sera, nasal washes, and in bronchopulmonary lavage fluids. In unprimed recipients, the relative frequency of serum antibody response and magnitude of rise was highest following the IM‐inactivated vaccine (100%) and lowest after IN‐live vaccine (29%). However, in individuals with pre‐existing antibody, the three vaccines given were comparably immunogenic. Occurrences of secretory IgA hemagglutinin antibody in nasal washings were more frequently associated with topical administration of live or inactivated vaccine, whereas, IgG hemagglutinin antibody responses occurred with equal frequency in nasal washings in all three vaccine groups. Analysis of the hemagglutinin antibody responses in the lower respiratory tract showed that the IN‐live vaccine favored the induction of secretory IgA hemagglutinin antibody and the IM‐inactivated vaccine stimulated a more frequent IgG hemagglutinin antibody response.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region><settlement><li>Houston</li></settlement></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="Zahradnik, John M" sort="Zahradnik, John M" uniqKey="Zahradnik J" first="John M." last="Zahradnik">John M. Zahradnik</name></region><name sortKey="Cate, Thomas R" sort="Cate, Thomas R" uniqKey="Cate T" first="Thomas R." last="Cate">Thomas R. Cate</name><name sortKey="Kasel, Julius A" sort="Kasel, Julius A" uniqKey="Kasel J" first="Julius A." last="Kasel">Julius A. Kasel</name><name sortKey="Martin, R Russell" sort="Martin, R Russell" uniqKey="Martin R" first="R. Russell" last="Martin">R. Russell Martin</name><name sortKey="Six, Howard R" sort="Six, Howard R" uniqKey="Six H" first="Howard R." last="Six">Howard R. Six</name><name sortKey="Zahradnik, John M" sort="Zahradnik, John M" uniqKey="Zahradnik J" first="John M." last="Zahradnik">John M. Zahradnik</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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